BS7968

antibody from Bioworld Technology, Inc
Targeting: ATXN1 ATX1, D6S504E, SCA1
Provider product page for BS7968
Western blot
Immunohistochemistry

Antibody data

Product number
BS7968 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Ataxin 1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Ataxin-1.
Description
Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ATXN1 protein structure - BS7968 shown in red.