Tissue expression
Cell line expression
Protein structure
IL12RB2
Interleukin 12 receptor subunit beta 2The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Top validated antibodies |
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antibodies-online | ABIN952881 | 3 references | Polyclonal |
WB
IHC
FC
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Invitrogen Antibodies | PA5-141067 | Polyclonal |
WB
ICC
IHC
FC |
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Abgent | AP10687b | Polyclonal |
WB
IHC
FC
|
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Acris Antibodies GmbH | AP52184PU-N | Polyclonal |
WB
IHC
FC
|
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OriGene | AP52184PU-N | Polyclonal |
WB
IHC
FC
|
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