CARD14

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Description

Caspase recruitment domain family member 14

Tissue specificity

Tissue enhanced (esophagus, skin , vagina)

Subcell location

Aggresome, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (80169992 - 80209331)

Ensembl ID

ENSG00000141527  (ver. 103.38)

Orthologs

Mouse Card14: ENSMUSG00000013483

UniProt

Q9BXL6

neXtProt

NX_Q9BXL6

Human splice variants
Mouse splice variants

Protein structure