BS7899

antibody from Bioworld Technology, Inc
Targeting: SP100
Provider product page for BS7899
Western blot
Immunohistochemistry

Antibody data

Product number
BS7899 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SP100 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SP100.
Description
The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon-inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain. The homodimerization/ND-targeting region is considered a novel protein motif, termed HSR domain. SP-100 is also found to interact with Bright (B cell regulator of IgH transcription), which in lymphoid cells also interacts with LYSP100/SP140, the lymphoid-restricted homolog of SP100.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SP100 protein structure - BS7899 shown in red.