BS7938

antibody from Bioworld Technology, Inc
Targeting: SETDB1 ESET, KG1T, KIAA0067, KMT1E, TDRD21
Provider product page for BS7938
Western blot
Immunohistochemistry

Antibody data

Product number
BS7938 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SETDB1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SETDB1.
Description
ERG-associated protein with SET domain (ESET), also designated Histone H3-K9 methyltransferase 4 or SET domain bifurcated 1, is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SETDB1 protein structure - BS7938 shown in red.