Ab105163
antibody from Aladdin Scientific Corporation
Targeting: ARHGEF2
GEF-H1, GEFH1, KIAA0651, Lfc, LFP40, P40
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- Ab105163 - Provider product page
- Provider
- Aladdin Scientific Corporation
- Product name
- Recombinant GEF H1 Antibody
- Antibody type
- Recombinant
- Description
- Rabbit anti Human GEF H1 Antibody, Recombinant (R03-3D1), could be used for WB and so on.Application:WB: 1/500 – 1/1000Protein FunctionActivates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Antigen sequence
AA 956-986
- Antibody clone number
- R03-3D1
- Vial size
- 100μl,10μl,1ml,50μl
- Concentration
- 0,48 mg/ml
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
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