Tissue expression
Cell line expression
Protein structure
ALPL
Alkaline phosphatase, biomineralization associatedHOPS, TNALP, TNAP, TNSALP
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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Novus Biologicals | AF2910 | 12 references | Polyclonal |
WB
ICC
IP
IHC
FC
|
|
R&D Systems | AF2910 | 6 references | Polyclonal |
WB
ICC
IP
IHC
FC
|
|
Proteintech Group | 11187-1-AP | 61 references | Polyclonal |
WB
EL
IHC
FC |
|
Invitrogen Antibodies | 11187-1-AP | Polyclonal |
WB
ICC
IHC
FC
ChIP
OA |
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antibodies-online | ABIN1105293 | 2 references | Monoclonal |
WB
EL
IHC
FC |
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider