ABIN116931

antibody from antibodies-online

Targeting: LEFTY2 EBAF, LEFTA, LEFTYA, TGFB4

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN116931

Provider

antibodies-online

Product name

anti-Left-Right Determination Factor 2 (LEFTY2) antibody

Antibody type

Monoclonal

Antigen

A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.

Reactivity

Human, Mouse, Rat

Host

Mouse

Isotype

IgG

Antibody clone number

7C5G1H6H10

Vial size

0.1 mg

Concentration

1.0 mg/ml (by UV absorbance at 280 nm)

Storage

Store the antibody (undiluted) at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

References

Submitted references

Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor.

Ulloa L, Tabibzadeh S
The Journal of biological chemistry 2001 Jun 15;276(24):21397-404

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Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1.

Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallón J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC
Proceedings of the National Academy of Sciences of the United States of America 1999 Sep 28;96(20):11376-81

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Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.

Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N
Cell 1998 Dec 11;95(6):829-37

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lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.

Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H
Cell 1998 Aug 7;94(3):287-97