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Cell line expression
Protein structure
MAP3K7
Mitogen-activated protein kinase kinase kinase 7MEKK7, TAK1
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  12330-2-AP |
43 references | Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C808603 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-39743 |
1 references | Polyclonal |
WB
IHC
OA
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| Novus Biologicals | H00006885-M02 |
1 references | Monoclonal |
WB
EL
BN
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| antibodies-online | ABIN2842053 |
4 references | Polyclonal |
WB
IHC
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