Tissue expression
Cell line expression
Protein structure
TNFRSF18
TNF receptor superfamily member 18AITR, CD357, GITR
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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Novus Biologicals | ![]() |
2 references | Polyclonal |
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R&D Systems | ![]() |
2 references | Polyclonal |
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Cell Signaling Technology, Inc | ![]() |
Monoclonal |
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Biorbyt | ![]() |
Recombinant |
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