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- Antibody Data
- Antigen structure
- References [11]
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- Product number
- MAB1844-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human KIR2DL1/KIR2DS5 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human KIR2DL1/KIR2DS5 on transfected cells. It does not stain cells transfected with KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P43626- Isotype
- IgG
- Antibody clone number
- 143211
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions.
Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II multicenter trial on behalf of the Société Française de Greffe de Moelle Osseuse et Thérapie Cellulaire and Eurocord.
Severe Symptomatic Primary Human Cytomegalovirus Infection despite Effective Innate and Adaptive Immune Responses.
Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control.
Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy.
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells.
Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.
Kristensen AB, Kent SJ, Parsons MS
Journal of virology 2018 Jun 1;92(11)
Journal of virology 2018 Jun 1;92(11)
Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II multicenter trial on behalf of the Société Française de Greffe de Moelle Osseuse et Thérapie Cellulaire and Eurocord.
Nguyen S, Achour A, Souchet L, Vigouroux S, Chevallier P, Furst S, Sirvent A, Bay JO, Socié G, Ceballos P, Huynh A, Cornillon J, Francois S, Legrand F, Yakoub-Agha I, Michel G, Maillard N, Margueritte G, Maury S, Uzunov M, Bulabois CE, Michallet M, Clement L, Dauriac C, Bilger K, Lejeune J, Béziat V, Rocha V, Rio B, Chevret S, Vieillard V
Bone marrow transplantation 2017 Oct;52(10):1428-1435
Bone marrow transplantation 2017 Oct;52(10):1428-1435
Severe Symptomatic Primary Human Cytomegalovirus Infection despite Effective Innate and Adaptive Immune Responses.
Riou R, Bressollette-Bodin C, Boutoille D, Gagne K, Rodallec A, Lefebvre M, Raffi F, Senitzer D, Imbert-Marcille BM, Retière C
Journal of virology 2017 Mar 1;91(5)
Journal of virology 2017 Mar 1;91(5)
Activating Killer Immunoglobulin Receptors and HLA-C: a successful combination providing HIV-1 control.
Malnati MS, Ugolotti E, Monti MC, Battista D, Vanni I, Bordo D, Sironi F, Larghero P, Marco ED, Biswas P, Poli G, Vicenzi E, Riva A, Tarkowski M, Tambussi G, Nozza S, Tripodi G, Marras F, De Maria A, Pistorio A, Biassoni R
Scientific reports 2017 Feb 13;7:42470
Scientific reports 2017 Feb 13;7:42470
Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.
Kennedy PR, Chazara O, Gardner L, Ivarsson MA, Farrell LE, Xiong S, Hiby SE, Colucci F, Sharkey AM, Moffett A
Journal of immunology (Baltimore, Md. : 1950) 2016 Dec 1;197(11):4292-4300
Journal of immunology (Baltimore, Md. : 1950) 2016 Dec 1;197(11):4292-4300
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 1;195(9):4524-36
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 1;195(9):4524-36
Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy.
Huijskens MJ, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers BL, Tilanus MG, Bos GM, Wieten L, Germeraad WT
Cytotherapy 2015 May;17(5):613-20
Cytotherapy 2015 May;17(5):613-20
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.
Enqvist M, Ask EH, Forslund E, Carlsten M, Abrahamsen G, Béziat V, Andersson S, Schaffer M, Spurkland A, Bryceson Y, Önfelt B, Malmberg KJ
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4518-27
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4518-27
Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.
Charoudeh HN, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
European journal of immunology 2013 Feb;43(2):480-7
European journal of immunology 2013 Feb;43(2):480-7
Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells.
Denman CJ, Senyukov VV, Somanchi SS, Phatarpekar PV, Kopp LM, Johnson JL, Singh H, Hurton L, Maiti SN, Huls MH, Champlin RE, Cooper LJ, Lee DA
PloS one 2012;7(1):e30264
PloS one 2012;7(1):e30264
Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.
Bari R, Bell T, Leung WH, Vong QP, Chan WK, Das Gupta N, Holladay M, Rooney B, Leung W
Blood 2009 Dec 10;114(25):5182-90
Blood 2009 Dec 10;114(25):5182-90
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of KIR2DL1/KIR2DS5 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with (A) Mouse Anti-Human KIR2DL1/KIR2DS5 Monoclonal Antibody (Catalog # MAB1844) or (B) Mouse IgG1 Isotype Control Antibody (Catalog # MAB002) followed by Anti-Mouse IgG APC-conjugated Secondary Antibody (Catalog # F0101B) and Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P). View our protocol for Staining Membrane-associated Proteins.
