FAB1844F-025

antibody from R&D Systems

Targeting: KIR2DL1 47.11, CD158A, cl-42, nkat1, p58.1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

FAB1844F-025

Provider

R&D Systems

Product name

Human KIR2DL1/KIR2DS5 Fluorescein-conjugated Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human KIR2DL1/KIR2DS5 on transfected cells. It does not stain cells transfected with KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1.

Reactivity

Human

Host

Mouse

Antigen sequence

P43626


Isotype

IgG

Antibody clone number

143211

Vial size

25 Tests

Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.

References

Submitted references

New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells.

Rettman P, Willem C, David G, Riou R, Legrand N, Esbelin J, Cesbron A, Senitzer D, Gagne K, Retière C
Journal of leukocyte biology 2016 Sep;100(3):471-9

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Human Cytomegalovirus Infection Enhances NK Cell Activity In Vitro.

Tschan-Plessl A, Stern M, Schmied L, Retière C, Hirsch HH, Garzoni C, van Delden C, Boggian K, Mueller NJ, Berger C, Villard J, Manuel O, Meylan P, Terszowski G
Transplantation direct 2016 Jul;2(7):e89

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Uptake of CCR7 by KIR2DS4⁺ NK cells is induced upon recognition of certain HLA-C alleles.

Pesce S, Carlomagno S, Moretta A, Sivori S, Marcenaro E
Journal of immunology research 2015;2015:754373

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The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.

Marquardt N, Ivarsson MA, Blom K, Gonzalez VD, Braun M, Falconer K, Gustafsson R, Fogdell-Hahn A, Sandberg JK, Michaëlsson J
Journal of immunology (Baltimore, Md. : 1950) 2015 Oct 1;195(7):3262-72

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Tissue-Specific Education of Decidual NK Cells.

Sharkey AM, Xiong S, Kennedy PR, Gardner L, Farrell LE, Chazara O, Ivarsson MA, Hiby SE, Colucci F, Moffett A
Journal of immunology (Baltimore, Md. : 1950) 2015 Oct 1;195(7):3026-32

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2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.

Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM
Genes and immunity 2015 Jul-Aug;16(5):301-10

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KIR/HLA interactions negatively affect rituximab- but not GA101 (obinutuzumab)-induced antibody-dependent cellular cytotoxicity.

Terszowski G, Klein C, Stern M
Journal of immunology (Baltimore, Md. : 1950) 2014 Jun 15;192(12):5618-24

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Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients.

Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, Samuel D, Debré P, Vieillard V, K-GREF Study Group.
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):503-11

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Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection.

Charoudeh HN, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M
European journal of immunology 2013 Feb;43(2):480-7

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Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motif.

Eller MA, Koehler RN, Kijak GH, Eller LA, Guwatudde D, Marovich MA, Michael NL, de Souza MS, Wabwire-Mangen F, Robb ML, Currier JR, Sandberg JK
Journal of virology 2011 May;85(10):4802-11

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Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.

Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaëlsson J, Malmberg KJ, Klingström J, Ahlm C, Ljunggren HG
The Journal of experimental medicine 2011 Jan 17;208(1):13-21

Flow cytometry

Supportive validation

Submitted by

R&D Systems (provider)

Main image

Experimental details

Detection of KIR2DL1/KIR2DS5 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human KIR2DL1/KIR2DS5 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1844F) and Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P). Quadrant markers were set based on isotype control antibody staining (Catalog # IC002F). View our protocol for Staining Membrane-associated Proteins.

Supportive validation

Submitted by

R&D Systems (provider)

Main image

Experimental details

Detection of KIR2DL1/KIR2DS5 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human KIR2DL1/KIR2DS5 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1844F) or (B) Mouse IgG1 Isotype Control Antibody (Catalog # IC002F) and Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P). View our protocol for Staining Membrane-associated Proteins.