12-1589-42
antibody from Invitrogen Antibodies
Targeting: KIR2DL1
47.11, CD158A, cl-42, nkat1, p58.1
Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 12-1589-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD158a/h/g Monoclonal Antibody (HP-MA4), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody HP-MA4 recognizes several CD158 proteins, also known as KIR2D, specifically KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g). It does not recognize KIR2DL2 (CD158b1), KIR2DS2 (CD158j), KIR2DL4 (CD158d) or KIR2DS4 (CD158i) and crossreactivity to KIR2DL3 (CD158b2) and KIR2DL5 (CD158f) are unknown. CD158 proteins are members of the killer cell immunoglobulin-like receptors (KIR) family of transmembrane glycoproteins that are expressed on NK cells and a subset of T cells. Each KIR has an isoform with either a short (S) or long (L) cytoplasmic domain which transduces either an activating or inhibitory signal, respectively. The crossreactivity of the HP-MA4 antibody to KIR2DS3 and KIR2DS5 was published in 2013.
- Conjugate
- Yellow dye
- Antibody clone number
- HP-MA4
- Concentration
- 5 µL/Test
Submitted references Peptide-specific engagement of the activating NK cell receptor KIR2DS1.
A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs.
Chapel A, Garcia-Beltran WF, Hölzemer A, Ziegler M, Lunemann S, Martrus G, Altfeld M
Scientific reports 2017 May 25;7(1):2414
Scientific reports 2017 May 25;7(1):2414
A comprehensive analysis of the binding of anti-KIR antibodies to activating KIRs.
Czaja K, Borer AS, Schmied L, Terszowski G, Stern M, Gonzalez A
Genes and immunity 2014 Jan;15(1):33-7
Genes and immunity 2014 Jan;15(1):33-7
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) APC (Product # 17-0567-42) and Mouse IgG2b K Isotype Control PE (Product # 12-4732-81) (left) or Anti-Human CD158a/h/g PE (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Yellow dye