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- References [10]
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- Immunohistochemistry [2]
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- Product number
- ABIN2849984 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 666-699), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 666-699, C-Term
- Antibody clone number
- RB10849
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.
Rubicon controls endosome maturation as a Rab7 effector.
Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells.
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.
Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus.
Sun Q, Zhang J, Fan W, Wong KN, Ding X, Chen S, Zhong Q
The Journal of biological chemistry 2011 Jan 7;286(1):185-91
The Journal of biological chemistry 2011 Jan 7;286(1):185-91
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.
Neely KM, Green KN, LaFerla FM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 23;31(8):2781-91
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 23;31(8):2781-91
Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.
Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP, Fimia GM, Piacentini M, Lovat PE
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Apr 15;17(8):2216-26
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Apr 15;17(8):2216-26
Rubicon controls endosome maturation as a Rab7 effector.
Sun Q, Westphal W, Wong KN, Tan I, Zhong Q
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 9;107(45):19338-43
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov 9;107(45):19338-43
Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.
Gao W, Kang JH, Liao Y, Ding WX, Gambotto AA, Watkins SC, Liu YJ, Stolz DB, Yin XM
The Journal of biological chemistry 2010 Jan 8;285(2):1371-83
The Journal of biological chemistry 2010 Jan 8;285(2):1371-83
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells.
Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H
The Journal of biological chemistry 2008 Jul 11;283(28):19665-77
The Journal of biological chemistry 2008 Jul 11;283(28):19665-77
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19211-6
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 9;105(49):19211-6
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU
Nature cell biology 2006 Jul;8(7):688-99
Nature cell biology 2006 Jul;8(7):688-99
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.
Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK
Oncogene 2004 Jan 22;23(3):639-45
Oncogene 2004 Jan 22;23(3):639-45
Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus.
Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D
Genomics 1997 May 1;41(3):397-405
Genomics 1997 May 1;41(3):397-405
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Supportive validation
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