GRIK1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Description

Glutamate ionotropic receptor kainate type subunit 1

Tissue specificity

Group enriched (adrenal gland, brain, retina)

Subcell location

Vesicles, Plasma membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

21 (29536933 - 29940033)

Ensembl ID

ENSG00000171189  (ver. 103.38)

Orthologs

Mouse Grik1: ENSMUSG00000022935

UniProt

P39086

neXtProt

NX_P39086

Human splice variants
Mouse splice variants

Protein structure