BS8281

antibody from Bioworld Technology, Inc
Targeting: GAMT PIG2, TP53I2
Provider product page for BS8281
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8281 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GAMT polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GAMT.
Description
In the creatine biosynthesis pathway, glycine is converted to guanidinoacetate by amidinotransferase, and guanidinoacetate is then converted to creatine by Guanidinoacetate N-methyltransferase (GAMT). GAMT, a methyltransferase, uses S-adenosylmethionine as the methyl donor for this reaction. Methyltransferases are a type of transferase enzyme which transfers a methyl group to nucleic bases in DNA or amino acids in protein. Encoding a 236 amino acid protein, the human GAMT gene maps to chromosome 19p13.3. Defects in the GAMT gene leads to GAMT deficiency, which is associated with guanidinoacetate accumulation and decreased levels of creatine excretion in brain. Such biochemical changes are thought to lead to various neurological syndromes and muscular hypotonia.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GAMT protein structure - BS8281 shown in red.