USP18

gene product
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
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58 antibodies from 16 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Abnova Corporation
7 antibodies
Novus Biologicals
10 antibodies
antibodies-online
18 antibodies
LifeSpan BioSciences, Inc.
3 antibodies
Atlas Antibodies
1 antibody
GeneTex
1 antibody
Thermo Fisher Scientific Pierce
1 antibody
Acris Antibodies GmbH
2 antibodies
Creative Biomart
5 antibodies
Cell Signaling Technology, Inc
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Aviva Systems Biology
2 antibodies
RabMAbs
1 antibody
Sigma-Aldrich
2 antibodies
Enzo Life Sciences
2 antibodies
EMD Millipore
1 antibody