AMM02427G

antibody from Leading Biology

Targeting: CST3

Western blot (Recommended by provider)

Antibody Data

Product number

AMM02427G

Provider

Leading Biology

Product name

CST3 Antibody

Antibody type

Monoclonal

Description

The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions, where they appear toprovide protective functions. The cystatin locus on chromosome 20contains the majority of the type 2 cystatin genes and pseudogenes.This gene is located in the cystatin locus and encodes the mostabundant extracellular inhibitor of cysteine proteases, which isfound in high concentrations in biological fluids and is expressedin virtually all organs of the body. A mutation in this gene hasbeen associated with amyloid angiopathy. Expression of this proteinin vascular wall smooth muscle cells is severely reduced in bothatherosclerotic and aneurysmal aortic lesions, establishing itsrole in vascular disease.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

572CT4.3.2

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.