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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN500796 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sprouty-Related, EVH1 Domain Containing 1 (SPRED1) (Center) antibody
- Antibody type
- Polyclonal
- Antigen
- Spred1 antibody was raised against a 20 amino acid peptide near the center of the human Spred1.
- Description
- Peptide affinity chromatography
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- Center
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8°C for up to one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.
Inhibition of angiogenesis by a mouse sprouty protein.
Spred is a Sprouty-related suppressor of Ras signalling.
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.
Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M
Oncogene 2006 Oct 5;25(45):6056-66
Oncogene 2006 Oct 5;25(45):6056-66
Inhibition of angiogenesis by a mouse sprouty protein.
Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL
The Journal of biological chemistry 2001 Feb 9;276(6):4128-33
The Journal of biological chemistry 2001 Feb 9;276(6):4128-33
Spred is a Sprouty-related suppressor of Ras signalling.
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A
Nature 2001 Aug 9;412(6847):647-51
Nature 2001 Aug 9;412(6847):647-51
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.
Minowada G, Jarvis LA, Chi CL, Neubüser A, Sun X, Hacohen N, Krasnow MA, Martin GR
Development (Cambridge, England) 1999 Oct;126(20):4465-75
Development (Cambridge, England) 1999 Oct;126(20):4465-75
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of Spred1 in mouse brain tissue lysate with AP30821PU-N at (A) 1 and (B) 2 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of Spred1 in human brain tissue with AP30821PU-N at 2.5 ?g/ml.
