Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- 14453-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14453-1-AP, RRID:AB_2073577
- Product name
- B7-H3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated B7-H3 antibody (Cat. #14453-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references B7-H3 suppresses CD8(+) T cell immunologic function through reprogramming glycolytic metabolism.
N6-methyladenosine modification of B7-H3 mRNA promotes the development and progression of colorectal cancer.
COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma.
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.
B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway.
PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma.
Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.
The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway.
Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis.
Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse.
B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer.
Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression.
Wu Y, Han W, Tang X, Liu J, Guo Z, Li Z, Cai C, Que L
Journal of Cancer 2024;15(9):2505-2517
Journal of Cancer 2024;15(9):2505-2517
N6-methyladenosine modification of B7-H3 mRNA promotes the development and progression of colorectal cancer.
Chen R, Su F, Zhang T, Wu D, Yang J, Guan Q, Chai C
iScience 2024 Feb 16;27(2):108956
iScience 2024 Feb 16;27(2):108956
COL10A1 promotes tumorigenesis by modulating CD276 in pancreatic adenocarcinoma.
Xu Q, Zheng J, Su Z, Chen B, Gu S
BMC gastroenterology 2023 Nov 16;23(1):397
BMC gastroenterology 2023 Nov 16;23(1):397
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD-L1 expression.
Zhang Q, Cao W, Yang C, Hong L, Geng S, Han H, Zhong C
The Journal of nutritional biochemistry 2023 Feb;112:109226
The Journal of nutritional biochemistry 2023 Feb;112:109226
B7-H3 confers stemness characteristics to gastric cancer cells by promoting glutathione metabolism through AKT/pAKT/Nrf2 pathway.
Xia L, Chen Y, Li J, Wang J, Shen K, Zhao A, Jin H, Zhang G, Xi Q, Xia S, Shi T, Li R
Chinese medical journal 2023 Aug 20;136(16):1977-1989
Chinese medical journal 2023 Aug 20;136(16):1977-1989
PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma.
Zhang H, Wang Y, Zhao Y, Liu T, Wang Z, Zhang N, Dai Z, Wu W, Cao H, Feng S, Zhang L, Cheng Q, Liu Z
CNS neuroscience & therapeutics 2022 Nov;28(11):1748-1766
CNS neuroscience & therapeutics 2022 Nov;28(11):1748-1766
Alpha-Fetoprotein Regulates the Expression of Immune-Related Proteins through the NF-κB (P65) Pathway in Hepatocellular Carcinoma Cells.
Li QT, Qiu MJ, Yang SL, Fang X, He XX, Wang MM, Li YN, Xiong ZF, Huang S
Journal of oncology 2020;2020:9327512
Journal of oncology 2020;2020:9327512
The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway.
Li Z, Liu J, Que L, Tang X
Journal of Cancer 2019;10(23):5770-5784
Journal of Cancer 2019;10(23):5770-5784
Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis.
Tang L, He S, Zhu Y, Feng B, Su Z, Liu B, Xu F, Wang X, Liu H, Li C, Zhao J, Zheng X, Li C, Sun C, Lu C, Zheng G
Journal of cellular physiology 2019 Apr;234(4):3661-3674
Journal of cellular physiology 2019 Apr;234(4):3661-3674
Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse.
Li K, Wei X, Zhang G, Li M, Zhang X, Zhou C, Hou J, Yuan H
BMC urology 2017 Apr 4;17(1):23
BMC urology 2017 Apr 4;17(1):23
B7-H3 in combination with regulatory T cell is associated with tumor progression in primary human non-small cell lung cancer.
Jin Y, Zhang P, Li J, Zhao J, Liu C, Yang F, Yang D, Gao A, Lin W, Ma X, Sun Y
International journal of clinical and experimental pathology 2015;8(11):13987-95
International journal of clinical and experimental pathology 2015;8(11):13987-95
Overexpression of B7-H3 in CD14+ monocytes is associated with renal cell carcinoma progression.
Li M, Zhang G, Zhang X, Lv G, Wei X, Yuan H, Hou J
Medical oncology (Northwood, London, England) 2014 Dec;31(12):349
Medical oncology (Northwood, London, England) 2014 Dec;31(12):349
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 14453-1-AP(CD276 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human medulloblastoma using 14453-1-AP(CD276 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human medulloblastoma using 14453-1-AP(CD276 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CD276 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD276. This antibody recognizes human,mouse,rat antigen. The CD276 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.