AMM01770G

antibody from Leading Biology

Targeting: CD276 B7-H3, B7H3, B7RP-2

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

AMM01770G

Provider

Leading Biology

Product name

CD276 / B7-H3 Antibody (clone MIH42)

Antibody type

Monoclonal

Description

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Reactivity

Human

Host

Mouse

Antibody clone number

MIH42

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.