331601

antibody from BioLegend

Targeting: CD276 B7-H3, B7H3, B7RP-2

Flow cytometry (Recommended by provider)

Antibody Data

Product number

331601

Provider

BioLegend

Product name

Purified anti-human CD276 (B7-H3)

Antibody type

Monoclonal

Antigen

CD276 (B7-H3)

Description

B7-H3 is a member of the B7 gene family. It has 88% amino acid sequence identity with mouse B7-H3. It is mostly expressed on professional APCs, including B cells, macrophages, and dendritic cells. Its expression on dendritic cells appears to be up-regulated by LPS. B7-H3 protein inhibits T cell activation and cytokine production. It was reported that monoclonal antibody against B7-H3 enhanced T cell proliferation in vitro and led to exacerbated EAE in vivo. Therefore, B7-H3 may be a negative regulator on T cell activation and function.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4 °C.