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Protein structure
TXNRD2
Thioredoxin reductase 2SELZ, TR, TR3, TRXR2
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Top validated antibodies |
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| Proteintech Group |  16360-1-AP |
12 references | Polyclonal |
WB
EL
IHC
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| LSBio | LS-C379996 |
Polyclonal |
WB
EL
IHC
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| Novus Biologicals | NBP1-86919 |
4 references | Polyclonal |
WB
IHC
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| Cusabio Biotech Co., Ltd | CSB-PA885675ESR2HU |
1 references | Polyclonal |
WB
EL
IHC
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| NovoPro Bioscience Inc. | 116459 |
Polyclonal |
WB
EL
ICC
IHC
|
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