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- Antibody Data
- Antigen structure
- References [16]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11019-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11019-2-AP, RRID:AB_2188830
- Product name
- SGTA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SGTA antibody (Cat. #11019-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.
Tumor suppressor REIC/Dkk-3 and its interacting protein SGTA inhibit glucocorticoid receptor to nuclear transport.
HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.
The canine prostate cancer cell line CHP-1 shows over-expression of the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α.
SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.
Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.
Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.
Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane.
The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration.
The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome.
Androgen receptor protein levels are significantly reduced in serous ovarian carcinomas compared with benign or borderline disease but are not altered by cancer stage or metastatic progression.
SGTA: a new player in the molecular co-chaperone game.
Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation.
Chen YJ, Williams JM, Arvan P, Tsai B
The Journal of cell biology 2020 Feb 3;219(2)
The Journal of cell biology 2020 Feb 3;219(2)
Tumor suppressor REIC/Dkk-3 and its interacting protein SGTA inhibit glucocorticoid receptor to nuclear transport.
Iwata T, Sadahira T, Ochiai K, Ueki H, Sasaki T, Haung P, Araki M, Watanabe T, Nasu Y, Watanabe M
Experimental and therapeutic medicine 2020 Aug;20(2):1739-1745
Experimental and therapeutic medicine 2020 Aug;20(2):1739-1745
HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.
Bohush A, Niewiadomska G, Weis S, Filipek A
Journal of Parkinson's disease 2019;9(1):97-107
Journal of Parkinson's disease 2019;9(1):97-107
The canine prostate cancer cell line CHP-1 shows over-expression of the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α.
Azakami D, Nakahira R, Kato Y, Michishita M, Kobayashi M, Onozawa E, Bonkobara M, Kobayashi M, Takahashi K, Watanabe M, Ishioka K, Sako T, Ochiai K, Omi T
Veterinary and comparative oncology 2017 Jun;15(2):557-562
Veterinary and comparative oncology 2017 Jun;15(2):557-562
SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.
Dupzyk A, Williams JM, Bagchi P, Inoue T, Tsai B
Journal of virology 2017 Jun 15;91(12)
Journal of virology 2017 Jun 15;91(12)
Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.
Philp LK, Day TK, Butler MS, Laven-Law G, Jindal S, Hickey TE, Scher HI, Butler LM, Tilley WD
Scientific reports 2016 Jun 30;6:28950
Scientific reports 2016 Jun 30;6:28950
Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.
Kato Y, Ochiai K, Michishita M, Azakami D, Nakahira R, Morimatsu M, Ishiguro-Oonuma T, Yoshikawa Y, Kobayashi M, Bonkobara M, Kobayashi M, Takahashi K, Watanabe M, Omi T
Veterinary journal (London, England : 1997) 2015 Nov;206(2):143-8
Veterinary journal (London, England : 1997) 2015 Nov;206(2):143-8
Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
Novosylna O, Jurewicz E, Pydiura N, Goral A, Filipek A, Negrutskii B, El'skaya A
Biochimie 2015 Dec;119:137-45
Biochimie 2015 Dec;119:137-45
A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane.
Ravindran MS, Bagchi P, Inoue T, Tsai B
PLoS pathogens 2015 Aug;11(8):e1005086
PLoS pathogens 2015 Aug;11(8):e1005086
The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration.
Bagchi P, Walczak CP, Tsai B
Journal of virology 2015 Apr;89(8):4058-68
Journal of virology 2015 Apr;89(8):4058-68
The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.
Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB
The Journal of biological chemistry 2014 May 30;289(22):15297-308
The Journal of biological chemistry 2014 May 30;289(22):15297-308
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.
Walczak CP, Ravindran MS, Inoue T, Tsai B
PLoS pathogens 2014 Mar;10(3):e1004007
PLoS pathogens 2014 Mar;10(3):e1004007
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome.
Butler MS, Yang X, Ricciardelli C, Liang X, Norman RJ, Tilley WD, Hickey TE
Fertility and sterility 2013 Jun;99(7):2076-83.e1
Fertility and sterility 2013 Jun;99(7):2076-83.e1
Androgen receptor protein levels are significantly reduced in serous ovarian carcinomas compared with benign or borderline disease but are not altered by cancer stage or metastatic progression.
Butler MS, Ricciardelli C, Tilley WD, Hickey TE
Hormones & cancer 2013 Jun;4(3):154-64
Hormones & cancer 2013 Jun;4(3):154-64
SGTA: a new player in the molecular co-chaperone game.
Philp LK, Butler MS, Hickey TE, Butler LM, Tilley WD, Day TK
Hormones & cancer 2013 Dec;4(6):343-57
Hormones & cancer 2013 Dec;4(6):343-57
Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation.
Trotta AP, Need EF, Selth LA, Chopra S, Pinnock CB, Leach DA, Coetzee GA, Butler LM, Tilley WD, Buchanan G
International journal of cancer 2013 Dec 15;133(12):2812-23
International journal of cancer 2013 Dec 15;133(12):2812-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11019-2-AP(SGTA antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SGTA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SGTA. This antibody recognizes human,mouse,rat antigen. The SGTA antibody has been validated for the following applications: ELISA, IHC, WB analysis.
