BS7822

antibody from Bioworld Technology, Inc
Targeting: QDPR DHPR, PKU2, SDR33C1
Provider product page for BS7822
Western blot
Immunohistochemistry

Antibody data

Product number
BS7822 - Provider product page
Provider
Bioworld Technology, Inc
Product name
QDPR polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human QDPR.
Description
QDPR (quinoid dihydropteridine reductase), also known as DHPR (dihydropteridine reductasae) or PKU2, is a member of the short-chain dehydrogenases/reductase (SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine). More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II (also called PK2 or dihydropteridine reductase deficiency), a disorder resulting from the depletion of dopamine, epinephrine and serotonin due to defective recycling of BH4. Symptoms of PK2 include hyperphenylalaninemia, axial hypotonia, truncal hypertonia, microcephaly and abnormal thermogenesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
QDPR protein structure - BS7822 shown in red.