BS8545

antibody from Bioworld Technology, Inc
Targeting: TXN2 MT-TRX
Provider product page for BS8545
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8545 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Trx2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; Thioredoxin 2; Thioredoxin2; TXN2; TRX-2
Description
Thioredoxin 2 (Trx-2) is a small redox protein that is localized to the mitochondria and is essential for cell viability, playing a crucial role in the scavenging of ROS in mitochondria and regulating the mitochondrial apoptosis signaling pathway. Trx reductases (TrxR1 and TrxR2) are ubiquitously expressed flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TXN2 protein structure - BS8545 shown in red.