CHAC1

This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]

Description

ChaC glutathione specific gamma-glutamylcyclotransferase 1

Tissue specificity

Tissue enhanced (pancreas, skeletal muscle)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (40952962 - 40956512)

Ensembl ID

ENSG00000128965  (ver. 103.38)

Orthologs

Mouse Chac1: ENSMUSG00000027313

UniProt

Q9BUX1

neXtProt

NX_Q9BUX1

Human splice variants
Mouse splice variants

Protein structure