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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF1210 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Growth Hormone R/GHR Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Growth Hormone R/GHR in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse GHR and recombinant rat GHR is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P10912- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references The Leukocyte Immunoglobulin-Like Receptor Family Member LILRB5 Binds to HLA-Class I Heavy Chains.
Growth hormone promotes lymphangiogenesis.
Zhang Z, Hatano H, Shaw J, Olde Nordkamp M, Jiang G, Li D, Kollnberger S
PloS one 2015;10(6):e0129063
PloS one 2015;10(6):e0129063
Growth hormone promotes lymphangiogenesis.
Banziger-Tobler NE, Halin C, Kajiya K, Detmar M
The American journal of pathology 2008 Aug;173(2):586-97
The American journal of pathology 2008 Aug;173(2):586-97
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Growth Hormone R/GHR Inhibition of Growth Hormone-dependent Cell Proliferation and Neutralization by Human Growth Hormone R/GHR Antibody. Recombinant Human Growth Hormone R/GHR Fc Chimera (Catalog # 1210-GR) inhibits Recombinant Human Growth Hormone (Catalog # 1067-GH) induced proliferation in the Nb2-11 rat lymphoma cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human Growth Hormone (0.2 ng/mL) activity elicited by Recombinant Human Growth Hormone R/GHR Fc Chimera (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human Growth Hormone R/GHR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1210). The ND50 is typically 0.125-0.5 µg/mL.
