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Protein structure
IDH3B
Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit betaRP46
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2016]
Top validated antibodies |
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| Atlas Antibodies |  HPA049387 |
Polyclonal |
WB
ICC
IHC
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| antibodies-online | ABIN2838549 |
4 references | Polyclonal |
WB
IHC
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| Invitrogen Antibodies | PA5-61951 |
Polyclonal |
WB
ICC
IHC
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| Novus Biologicals | NBP1-78787 |
1 references | Polyclonal |
WB
EL
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| NovoPro Bioscience Inc. | 140263 |
Polyclonal |
WB
EL
IHC
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