CLEC14A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

Description

C-type lectin domain containing 14A

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Golgi apparatus

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (38254000 - 38256093)

Ensembl ID

ENSG00000176435  (ver. 103.38)

Orthologs

Mouse Clec14a: ENSMUSG00000045930

UniProt

Q86T13

neXtProt

NX_Q86T13

Human splice variants
Mouse splice variants

Protein structure