Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- MAB1381-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human NKG2C/CD159c Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 134522
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8⁺ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia.
Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.
Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
NFKB1 regulates human NK cell maturation and effector functions.
Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection.
NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus.
Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components.
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
Pump WC, Kraemer T, Huyton T, Hò GT, Blasczyk R, Bade-Doeding C
International journal of molecular sciences 2019 Mar 22;20(6)
International journal of molecular sciences 2019 Mar 22;20(6)
Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.
Ye W, Chew M, Hou J, Lai F, Leopold SJ, Loo HL, Ghose A, Dutta AK, Chen Q, Ooi EE, White NJ, Dondorp AM, Preiser P, Chen J
PLoS pathogens 2018 Oct;14(10):e1007298
PLoS pathogens 2018 Oct;14(10):e1007298
Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
Redondo-Pachón D, Crespo M, Yélamos J, Muntasell A, Pérez-Sáez MJ, Pérez-Fernández S, Vila J, Vilches C, Pascual J, López-Botet M
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):94-101
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):94-101
NFKB1 regulates human NK cell maturation and effector functions.
Lougaris V, Patrizi O, Baronio M, Tabellini G, Tampella G, Damiati E, Frede N, van der Meer JWM, Fliegauf M, Grimbacher B, Parolini S, Plebani A
Clinical immunology (Orlando, Fla.) 2017 Feb;175:99-108
Clinical immunology (Orlando, Fla.) 2017 Feb;175:99-108
Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection.
Chiu CY, Sánchez-San Martín C, Bouquet J, Li T, Yagi S, Tamhankar M, Hodara VL, Parodi LM, Somasekar S, Yu G, Giavedoni LD, Tardif S, Patterson J
Scientific reports 2017 Dec 7;7(1):17126
Scientific reports 2017 Dec 7;7(1):17126
NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.
Anton OM, Vielkind S, Peterson ME, Tagaya Y, Long EO
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4810-21
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4810-21
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 1;195(9):4524-36
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 1;195(9):4524-36
Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus.
Costa-Garcia M, Vera A, Moraru M, Vilches C, López-Botet M, Muntasell A
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2715-24
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2715-24
Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.
Heatley SL, Pietra G, Lin J, Widjaja JM, Harpur CM, Lester S, Rossjohn J, Szer J, Schwarer A, Bradstock K, Bardy PG, Mingari MC, Moretta L, Sullivan LC, Brooks AG
The Journal of biological chemistry 2013 Mar 22;288(12):8679-90
The Journal of biological chemistry 2013 Mar 22;288(12):8679-90
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components.
Alici E, Sutlu T, Björkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS
Blood 2008 Mar 15;111(6):3155-62
Blood 2008 Mar 15;111(6):3155-62
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B
Blood 2007 Apr 1;109(7):2806-14
Blood 2007 Apr 1;109(7):2806-14
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Detection of NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c Monoclonal Antibody (Catalog # MAB1381) or (B) Mouse IgG2B Flow Cytometry Isotype Control (Catalog # MAB0041) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.