SORCS1

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

Sortilin related VPS10 domain containing receptor 1

Tissue specificity

Tissue enhanced (brain, retina, thyroid gland)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

10 (106573663 - 107164534)

Ensembl ID

ENSG00000108018  (ver. 103.38)

Orthologs

Mouse Sorcs1: ENSMUSG00000043531

UniProt

Q8WY21

neXtProt

NX_Q8WY21

Human splice variants
Mouse splice variants

Protein structure