Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
NUP98
Nucleoporin 98 and 96 precursorNUP96, Nup98-96, Nup98-Nup96
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Top validated antibodies |
|||||
| Proteintech Group |  12329-1-AP |
2 references | Polyclonal |
WB
EL
IP
IHC
|
|
| Novus Biologicals | NB100-93325 |
4 references | Polyclonal |
WB
ICC
IP
|
|
| antibodies-online | ABIN2452064 |
2 references | Monoclonal |
WB
ICC
IHC
|
|
| Abnova Corporation | MAB6758 |
4 references | Monoclonal |
WB
ICC
|
|
| Invitrogen Antibodies | 12329-1-AP |
Polyclonal |
WB
IHC
OA
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider