BS6206

antibody from Bioworld Technology, Inc
Targeting: ARRB2 ARR2, BARR2, DKFZp686L0365
Provider product page for BS6206
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6206 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Arrestin ÉÇ 2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Arrestin-ÉÇ-2.
Description
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ARRB2 protein structure - BS6206 shown in red.