DCABH-1479

antibody from Creative Diagnostics

Targeting: ARRB2 ARR2, BARR2, DKFZp686L0365

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-1479

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-1479, RRID:AB_2475450

Product name

Anti-ARRB2 monoclonal antibody, clone 4H2

Antibody type

Monoclonal

Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

4H2

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.