RGCC

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

Description

Regulator of cell cycle

Tissue specificity

Tissue enhanced (bone marrow, lung)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13 (41457550 - 41470871)

Ensembl ID

ENSG00000102760  (ver. 103.38)

Orthologs

Mouse Rgcc: ENSMUSG00000022018

UniProt

Q9H4X1

neXtProt

NX_Q9H4X1

Human splice variants
Mouse splice variants

Protein structure