TPO

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Description

Thyroid peroxidase

Tissue specificity

Tissue enriched (thyroid gland)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

2 (1374066 - 1543711)

Ensembl ID

ENSG00000115705  (ver. 103.38)

Orthologs

Mouse Tpo: ENSMUSG00000020673

UniProt

P07202

neXtProt

NX_P07202

Human splice variants
Mouse splice variants

Protein structure