CCNDBP1

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]

Description

Cyclin D1 binding protein 1

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (43185118 - 43197177)

Ensembl ID

ENSG00000166946  (ver. 103.38)

Orthologs

Mouse Ccndbp1: ENSMUSG00000023572

UniProt

O95273

neXtProt

NX_O95273

Human splice variants
Mouse splice variants

Protein structure