CABT-RM178

antibody from Creative Diagnostics

Targeting: MARVELD2 DFNB49, FLJ30532, MRVLDC2, TRIC

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-RM178

Provider

Creative Diagnostics

Product name

Rat Anti-MARVELD2 monoclonal antibody, clone O65

Antibody type

Monoclonal

Description

MARVEL domain-containing protein 2 is encoded by the Marveld2 gene in murine species. Tricellulin is a multi-pass membrane protein that is predominantly detected in small intestine, lung, and kidney and lower levels are detected in liver, testis, and brain. It is a member of the tight junction-associated Marvel protein family, which consists of occludin, tricellulin, and Marveld3. Tricellulin contains four transmembrane domains, two extracellular loops and large amino- and carboxyl-terminal cytoplasmic domains. It plays a role in the formation of tricellular tight junctions and of epithelial barriers and regulates F-actin organization through Cdc42. It is shown to bind to the Cdc42 guanine-nucleotide-exchange factor (GEF) Tuba via its N-terminal cytoplasmic domain and activate Cdc42, thereby accelerating organization of F-actin fibers at tricellular contacts. Tricellulin-knockdown epithelial cells exhibit irregular polygonal shapes with curved cell borders and impaired organization of F-actin fibers around tricellular contacts during cell-cell junction formation. Tricellulin is reported to be essential for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti. Mutations in Marveld2 gene are reported to cause nonsyndromic familial deafness.

Reactivity

Mouse

Host

Rat

Conjugate

Unconjugated

Isotype

IgG