CABT-B9227

antibody from Creative Diagnostics

Targeting: KPNA3 hSRP1, IPOA4, SRP1gamma, SRP4

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9227

Provider

Creative Diagnostics

Product name

Mouse anti-Human Karyopherin Ï« monoclonal antibody, clone 3

Antibody type

Monoclonal

Description

The two step process of importing proteins into the nucleus involves the binding and interaction of several cytosolic and nuclear pore proteins. Proteins to be translocated into the nucleus contain a nuclear localization sequence (NLS) which is recognized and bound by carrier proteins in the cytosol. Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. The Ï«-subunits appear to function in the binding of NLS (both simple and bitartite NLS motifs), but both Ï«- and ÉÇ-subunits are required for successful docking to the nuclear envelope. ATP is required for complete translocation of proteins into the nucleus. Karyopherin Ï«2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. Rch-1 has been reported to be 44% identical to karyopherin Ï«1 (hSRP-1 /NPI-1).

Reactivity

Human, Mouse, Rat, Canine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.