NAA60

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

Description

N-alpha-acetyltransferase 60, NatF catalytic subunit

Tissue specificity

Low tissue specificity

Subcell location

Actin filaments, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

16 (3443649 - 3486953)

Ensembl ID

ENSG00000122390  (ver. 103.38)

Orthologs

Mouse Naa60: ENSMUSG00000005982

UniProt

Q9H7X0

neXtProt

NX_Q9H7X0

Human splice variants
Mouse splice variants

Protein structure