CABT-B9331

antibody from Creative Diagnostics

Targeting: SYT5

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-B9331

Provider

Creative Diagnostics

Product name

Mouse anti-Rat Synaptotagmin V monoclonal antibody, clone 57

Antibody type

Monoclonal

Description

Synaptotagmin I belongs to a family of C2 domain containing proteins, which include Synatotagmin II to XI and Srg1. All of the members of this protein family contain a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C (C2A and C2B domains). Synaptotagmin I-V and IX-XI are found in brain, while synaptotagmin VI-VIII are found in non-neuronal tissues. Synaptotagmin I and II have regulatory roles in synaptic vesicle docking and fusion with the plasmalemma. Both synaptotagmin I and II act as vSNAREs that form a complex with SNAP-25 and syntaxin at the plasma membrane. This complex is required for rapid, calcium-dependent synaptic vesicle exocytosis. In addition to their roles in exocytosis, synaptotagmin I and II can bind to calcium channels, calmodulin, and the clathrin adaptor protein AP-2. Synatotagmins III, V, VI, and X cannot bind IP4 like other synaptotagmins, but like most synaptotagmins these family members form heteromers with other synaptotagmins. Synaptotagmins IV, X, and Srg1 may regulate vesicular trafficking during brain development and plasticity. In neuronal and non-neuronal tissues, synaptotagmins may be important for vesicle exocytosis, endocytosis, and trafficking, as well calcium signaling.

Reactivity

Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

57

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.