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Protein structure
TNFSF9
TNF superfamily member 94-1BB-L, 4-1BBL
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [provided by RefSeq, Oct 2008]
Top validated antibodies |
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| Novus Biologicals |  AF2295 |
2 references | Polyclonal |
WB
IHC
FC
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| R&D Systems | AF2295 |
2 references | Polyclonal |
WB
IHC
FC
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| antibodies-online | ABIN2658422 |
Monoclonal |
WB
EL
IHC
FC
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| Proteintech Group | 66450-1-Ig |
4 references | Monoclonal |
WB
EL
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| Invitrogen Antibodies | 8744-MSM1-P0 |
Monoclonal |
IHC
FC
OA
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