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ITPR2
Inositol 1,4,5-trisphosphate receptor type 2CFAP48, IP3R2
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Top validated antibodies |
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| Invitrogen Antibodies |  PA1-904 |
12 references | Polyclonal |
ICC
IHC
FC
OA
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| Novus Biologicals | NB100-2466 |
6 references | Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN250904 |
5 references | Polyclonal |
WB
EL
ICC
|
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| GeneTex | GTX82888 |
Polyclonal |
WB
ICC
IHC
FC
|
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| Antibodies.com | A52965 |
Polyclonal |
WB
EL
IP
IHC
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