ANKRD17

The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Description

Ankyrin repeat domain 17

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (73073376 - 73258798)

Ensembl ID

ENSG00000132466  (ver. 103.38)

Orthologs

Mouse Ankrd17: ENSMUSG00000055204

UniProt

O75179

neXtProt

NX_O75179

Human splice variants
Mouse splice variants

Protein structure