PPL

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Description

Periplakin

Tissue specificity

Tissue enhanced (esophagus, vagina)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (4882507 - 4960741)

Ensembl ID

ENSG00000118898  (ver. 103.38)

Orthologs

Mouse Ppl: ENSMUSG00000039457

UniProt

O60437

neXtProt

NX_O60437

Human splice variants
Mouse splice variants

Protein structure