Tissue expression
Cell line expression
Protein structure
IL6ST
Interleukin 6 signal transducerCD130, GP130, sGP130
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Top validated antibodies |
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OriGene | AM31176AF-N | 1 references | Monoclonal |
WB
IP
IHC
FC
FA
|
|
GeneTex | GTX109048 | 3 references | Polyclonal |
WB
ICC
IHC
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|
Invitrogen Antibodies | MA5-38467 | Monoclonal |
WB
EL
ICC
IHC
FC
|
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LSBio | LS-C198749 | Polyclonal |
WB
EL
ICC
IHC |
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antibodies-online | ABIN1105847 | 22 references | Monoclonal |
WB
IP
FC
FA |
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