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IL6ST
Interleukin 6 signal transducerCD130, GP130, sGP130
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Top validated antibodies |
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| OriGene |  AM31176AF-N |
1 references | Monoclonal |
WB
IP
IHC
FC
FA
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| LSBio | LS-C198749 |
Polyclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX109048 |
3 references | Polyclonal |
WB
ICC
IHC
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| antibodies-online | ABIN1105847 |
22 references | Monoclonal |
WB
IP
FC
FA
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| Novus Biologicals | AF468 |
3 references | Polyclonal |
WB
FC
BN
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