UCMA

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Description

Upper zone of growth plate and cartilage matrix associated

Tissue specificity

Tissue enhanced (brain, ovary)

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

10 (13221766 - 13234374)

Ensembl ID

ENSG00000165623  (ver. 103.38)

Orthologs

Mouse Ucma: ENSMUSG00000026668

UniProt

Q8WVF2

neXtProt

NX_Q8WVF2

Human splice variants
Mouse splice variants

Protein structure