ZCRB1

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Description

Zinc finger CCHC-type and RNA binding motif containing 1

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (42312086 - 42326257)

Ensembl ID

ENSG00000139168  (ver. 103.38)

Orthologs

Mouse Zcrb1: ENSMUSG00000022635

UniProt

Q8TBF4

neXtProt

NX_Q8TBF4

Human splice variants
Mouse splice variants

Protein structure