SRSF5

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Description

Serine and arginine rich splicing factor 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (69726900 - 69772005)

Ensembl ID

ENSG00000100650  (ver. 103.38)

Orthologs

Mouse Srsf5: ENSMUSG00000021134

UniProt

Q13243

neXtProt

NX_Q13243

Human splice variants
Mouse splice variants

Protein structure